I learned last year that if you have a star performer with an injury who is questionable and is scheduled to play on Monday night, grab another player (teammate or from the opponent's team) at the same position for your bench.
That way, if it is announced that your star is unable to go right before kickoff, you have another player to insert into your lineup.
Otherwise, you have to play someone else prior to Monday's game or take a risk that might leave you with a zero point performance by your injured guy.
This week, I am watching the Giants' WR Nicks and his bad knee. If he can't play on Monday, I also have the Giants WR Manningham.
Hopefully, Nicks will be a go--I like the Giants having a good offensive showing after a poor showing in Week #1 and playing a banged-up Rams squad.